A Review on Computational Methods for Predicting Residue-Specific Stabilities of Proteins
نویسنده
چکیده
Residue-specific stabilities of proteins can be reliably determined by using NMR-monitored hydrogen/deuterium exchange (NMR-H/D) methods under native conditions. Notwithstanding the potential advantages of the NMR-H/D methods, they are time consuming, very expensive and technically challenging. In this review article, various computational tools and strategies reported to date in the literature on predicting the residue-specific free energy (∆GHX) of proteins have been comprehensively exemplified. Moreover, scopes to develop novel computational tools for estimating ∆GHX values of proteins have also been discussed.
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تاریخ انتشار 2015